세포분자생리학/신경과학특론(3학년선택)

다음 참고 자료 중 1개를 선택, 아래 세 항목을 포함하는 요약을 A4 2 pages 내외의 pdf 형식으로 제출하세요. (제출처: caramelapple@서울대)

• Research Question: 어떤 질문(명제)를 테스트 하고자 했는지 + 그러한 질문이 나온 배경은 무엇인지?

• Methods & Results: 위 질문(명제)의 가/부를 어떠한 방법으로 테스트했는지? 테스트 결과는 무엇인지?

• Discussion(결론): 얻어진 결과를 토대로 어떠한 결론을 내릴 수 있는지? 또 다른 해석이 가능한지? 그 다른 해석을 배제하기 위해 추가할 테스트는 어떤 것이 있는지..?

참고자료 (2018)

1. Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell Metabolism (2018.03)

2. Hierarchical neural architecture underlying thirst regulation. Nature (2018.03)

3. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature (2018.03)

4. Microneedle-based device for the one-step painless collection of capillary blood samples Nature Biomedical Engineering (2018.03)

5. Caffeine consumption disrupts hippocampal long-term potentiation in freely behaving rats. Physiological Reports (2018.03)

6. CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection. PLOS Pathogens (2018.03)

7. Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice. Neuron (2018.02)

8. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell (2018.02)

9. Structure of the mechanically activated ion channel Piezo1. Nature (2018.02)

10. Structure and mechanogating mechanism of the Piezo1 channel. Nature (2018.02)

참고자료 (2017)

1. Reversing behavioural abnormalities in mice exposed to maternal inflammation. Nature (2017.09)

2. Sex-specific transcriptional signatures in human depression. Nature Medicine (2017.09)

3. Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging. Nature Neuroscience (2017.08)

4. Ultrasound-triggered local anaesthesia. Nature Biomedical Engineering (2017.08)

5. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nature Medicine (2017.08)

6. Reduced Mastication Impairs Memory Function. Journal of Dental Research (2017.06)

7. The cellular mechanism for water detection in the mammalian taste system. Nature Neuroscience (2017.05)

8. A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nature Medicine (2017.05)

9. A nontoxic pain killer designed by modeling of pathological receptor conformations. Science (2017.03)

참고자료 (Classic)

1. The molecular mechanisms controlling circadian rhythm. 노벨 생리/의학 2017

2. Spatial Representation in the Entorhinal Cortex. Science (2004) - 노벨 생리/의학 2014

3. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition Cell (1991) - 노벨 생리/의학 2004

4. Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) - 노벨 화학 2012